Scientific Overview

Vitivia® is a non‑hormonal Vitamin E suppository formulated for vaginal and rectal administration, designed to support genital tissue integrity, hydration, and mucosal health.

The product contains natural d‑alpha tocopheryl acetate and tocopherol, offering potent local antioxidant and anti‑inflammatory effects with minimal systemic exposure.

Vitivia® is particularly suitable for individuals who require an alternative or adjunct to hormonal therapies, especially in conditions associated with estrogen deficiency or mucosal fragility.

Mechanism of Action

Studies evaluating the effect of β‐glucans on immune and inflammatory biomarkers and infection in children

  • Potent antioxidant activity

– Neutralizes reactive oxygen species (ROS)

– Reduces oxidative stress in vaginal and rectal mucosa

Studies evaluating the effects of β‐glucans on immune and inflammatory biomarkers and infection in older adults

  • Anti‑inflammatory effects

– Decreases local inflammation

– Alleviates itching, burning, and irritation

Studies evaluating the effect of β‐glucans on immune and inflammatory biomarkers and infection in athletes

  • Epithelial repair and regeneration

– Enhances mucosal barrier function

– Supports tissue elasticity and moisture retention

Studies evaluating the effect of β‐glucans on immune and inflammatory biomarkers and health outcomes

  • Hormonal modulation (non‑hormonal approach)

– Exhibits mild anti‑estrogenic regulatory properties

– Helps balance estrogen‑related symptoms without systemic hormone exposure

Indications

  1. Vaginal Dryness

Vitivia® is indicated for the relief of vaginal dryness associated with:

  • Menopause and genitourinary syndrome of menopause (GSM)
  • Hormonal fluctuations
  • Use of certain medications
  • Postpartum or lactation‑related hypoestrogenism

Clinical manifestations addressed include dyspareunia, itching, irritation, and discomfort during daily activities.

2.Adjunctive Management of Vaginal Disorders

Vitivia® may be used as supportive therapy alongside standard treatments in:

  • Vaginal atrophy
  • Bacterial vaginosis
  • Vulvovaginal candidiasis
  • Lichen sclerosus

Its local antioxidant and tissue‑protective effects help improve mucosal resilience and patient‑reported quality of life.

3.Rectal Use

When administered rectally, Vitamin E suppositories may assist in:

  • Relief of occasional constipation
  • Lubrication and protection of rectal mucosa

Clinical Evidence

Multiple randomized and observational studies have demonstrated that vaginal Vitamin E:

  • Significantly improves symptoms of vaginal atrophy in postmenopausal women
  • Enhances vaginal moisture and elasticity
  • Improves quality‑of‑life scores comparable to conjugated estrogen vaginal cream in selected populations
  • Offers a well‑tolerated, non‑hormonal alternative with a favorable safety profile

Key Advantages

  • Non‑hormonal and locally acting
  • Suitable for long‑term use
  • Minimal systemic absorption
  • High tolerability
  • Free from parabens, phthalates, BPA, and PABA
  • Can be used vaginally or rectally
  • Appropriate for women of different age groups under medical supervision

Composition (per Suppository)

  • Natural Vitamin E (d‑alpha tocopheryl acetate + tocopherol) – 20 mg (30 IU)

Dosage & Administration

  • Vaginal use: Insert one suppository vaginally as prescribed by a healthcare professional.
  • Rectal use: Insert rectally for occasional constipation, according to medical advice.

Storage Conditions

  • Store at 15–25°C
  • If softening occurs, refrigerate until firm
  • Keep out of reach of children